Ep 118:Â "Triple G": What to Know About Retatrutide (vs. Semaglutide vs. Tirzepatide)
Retatrutide — nicknamed "Triple G" — has posted the largest weight-loss results ever seen from a medication, with about 28% average weight loss in its main phase 3 trial. Dr. Judith Borger breaks down how this investigational triple agonist works on GIP, GLP-1, and glucagon, what the phase 2 and phase 3 studies show, how it compares to semaglutide (Wegovy/Ozempic) and tirzepatide (Zepbound/Mounjaro), and why the "research peptide" versions sold online are a real risk.
In this episode
- How semaglutide and tirzepatide work, and the step from single to dual to triple agonist
- Why glucagon is the surprising — and important — third hormone
- Results from TRIUMPH-1 through -4 and TRANSCEND-T2D-1
- Side effects, including dysesthesia and what it means for your skin
- What's still unknown: head-to-head data, heart outcomes, lean mass
- The legal landscape
Ep 116: Peptides 101: What They Are, What’s Legal, and What’s Actually Worth Your Money
Join host Dr. Judith Borger in an educational and eye-opening episode of The Aesthetic Doctor Podcast: “Peptides 101: What They Are, What’s Legal, and What’s Actually Worth Your Money.”
Beyond the Peptide Hype
Peptides are everywhere right now, from social media wellness trends to aesthetic and longevity conversations. But what exactly are peptides, how do they work, and why is there so much confusion surrounding them?
From “Glow” to “Wolverine”
Dr. Borger breaks down some of the most talked-about peptides and peptide combinations, including GHK-Cu, BPC-157, TB-500, CJC-1295, Ipamorelin, PT-141, and GLP-1s, while exploring what we actually know about their potential benefits.
What’s Legal, What’s Regulated, and What’s Evidence-Based
This episode also takes a closer look at the evolving FDA regulatory landscape around compounded peptides and why “not on the safety watch list” does not automatically mean “FDA approved for compounding.” Dr. Borger explains the importance of understanding where your medications come from and why working with a licensed physician and legitimate compounding pharmacy matters.
Cutting Through the Noise
With peptides becoming increasingly popular online, it can be difficult to separate science from speculation. Dr. Borger helps listeners understand the difference between human clinical evidence, animal research, theoretical mechanisms, and marketing hype.
🎧 Tune in for an informative and evidence-based episode that will help you better understand peptides, the evolving regulatory landscape, and what’s actually worth paying attention to before putting anything in the syringe.
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About Dr. Judith Borger
- Mom of 3, Sought after speaker, Physician, Podcaster, Life & Business Coach
- Pilates and Peloton Enthusiast
- On a Mission to Empower Women to be their most Beautiful and Authentic Selves
- Lover of the Ocean, Traveling, and Fashion
What our listeners have to say...
Belle Hazel
As both a provider and a consumer, this podcast is a great way to quickly absorb the things you need to know in an easily digestible format. Dr. Borger does the research so you don’t have you. Wonderful easy listen in the car and a reminder to be kind to myself and my body!
Dr. Lil Surprenant
Inspirational! High quality, thoughtful information about aesthetics from an expert. But, I must confess that my favorite episode so far was lessons from Miraval…loved the wisdom there!
LadyDoc1982
Dr. Borger is the best! Dr. Borger provides clear, insightful advice. She is so thoughtful. Love her show and can’t wait for more episodes!
Moxiee18
Soooo good. Finally - up to date education from a true aesthetic medicine physician and thought leader in a fun format. Aesthetic medicine and life coaching all woven into one!
FTB_MD
Fabulous! Honest reputable information about aesthetics. This is the only woman I trust to tell me the real deal about aesthetic products and treatments. She knows her stuff!!
The Skin Real
Great review of aesthetics overall! Dr. Borger presents the intriguing but sometimes overwhelming field of aesthetics with truth and knowledge. A great listen in the car on my morning commute!